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What medicine to take for gastroesophageal refluxitis

2025-12-02 12:29:30 healthy

What medicine to take for gastroesophageal refluxitis

Gastroesophageal refluxitis (GERD) is a common digestive system disease, mainly characterized by the reflux of gastric acid into the esophagus, causing symptoms such as heartburn and chest pain. In recent years, with the accelerated pace of life and changes in dietary structure, the incidence of GERD has gradually increased. This article will combine the hot topics and hot content on the Internet in the past 10 days to introduce you to the drug treatment plan for gastroesophageal refluxitis in detail and provide structured data for reference.

1. Common symptoms of gastroesophageal refluxitis

The main symptoms of gastroesophageal reflux disease include:

  • Heartburn (burning sensation behind the breastbone)
  • Acid reflux (reflux of stomach contents into the mouth)
  • Chest pain (similar to angina)
  • Difficulty or pain swallowing
  • Chronic cough or throat discomfort

2. Commonly used drugs for gastroesophageal refluxitis

The following are commonly used drug categories and representative drugs for the treatment of gastroesophageal refluxitis:

drug classMechanism of actionRepresentative medicineThings to note
Proton pump inhibitors (PPIs)Inhibit gastric acid secretionOmeprazole, lansoprazole, pantoprazoleBe wary of the risk of osteoporosis with long-term use
H2 receptor antagonistReduce gastric acid secretionranitidine, famotidineLess effective than PPI, but with fewer side effects
AntacidsNeutralize stomach acidAluminum hydroxide, calcium carbonateQuickly relieves symptoms, but has a short duration of action
Gastrointestinal motility drugsAccelerate gastric emptyingDomperidone, MosaprideNeed to be combined with other drugs for better effect
Mucosal protectantProtect esophageal mucosaSucralfate, aluminum magnesium carbonateNeed to be taken on an empty stomach

3. Selection of drug treatment options

Treatment options vary depending on the severity of the condition:

Degree of illnessRecommended planCourse of treatment
Mild GERDUse antacids or H2 receptor antagonists as neededDiscontinue medication after symptoms subside
Moderate GERDStandard dose PPI (once daily)4-8 weeks
Severe GERDHigh-dose PPI (twice daily) or combination8-12 weeks or more
Refractory GERDPPI + prokinetic drug + mucosal protective agentindividualized treatment

4. Medication precautions

1. PPI drugs are recommended to be taken 30 minutes before breakfast for best results.

2. Avoid taking certain drugs together: for example, PPI may affect the efficacy of clopidogrel

3. Long-term use of PPI requires regular evaluation and supplementation of calcium and vitamin B12 when necessary.

4. When stopping the drug, the dose should be gradually reduced to avoid rebound gastric acid secretion.

5. Lifestyle adjustment

Medication needs to be combined with lifestyle changes for best results:

  • Avoid fatty, spicy, and acidic foods
  • Control your weight to avoid increased abdominal pressure
  • Don’t eat 3 hours before going to bed
  • Raise the head of the bed 15-20cm
  • Quit smoking and limit alcohol

6. Latest research progress

According to recent popular medical information:

1. New potassium ion competitive acid blockers (P-CAB) such as vonoraxin have faster onset of action and longer-lasting acid suppression effect than traditional PPIs.

2. The technology of minimally invasive surgery to treat GERD is constantly improving, but patients who are ineffective in drug treatment still need to choose carefully.

3. Regulation of intestinal flora may become a new direction in the treatment of GERD, and relevant research is ongoing.

7. When Do You Need Medical Treatment?

You should seek medical treatment promptly if the following situations occur:

  • Medication is ineffective for 2 weeks
  • Alarm symptoms such as difficulty swallowing and weight loss occur
  • Symptoms seriously affect quality of life
  • Long-term medication requires regular follow-up

Summary: The drug treatment for gastroesophageal refluxitis needs to be selected according to individual conditions. Proton pump inhibitors are currently the most effective drugs, but care must be taken to use them rationally. With lifestyle adjustments and regular follow-up, most patients can achieve good control.

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