What medicine to take for gastroesophageal refluxitis
Gastroesophageal refluxitis (GERD) is a common digestive system disease, mainly characterized by the reflux of gastric acid into the esophagus, causing symptoms such as heartburn and chest pain. In recent years, with the accelerated pace of life and changes in dietary structure, the incidence of GERD has gradually increased. This article will combine the hot topics and hot content on the Internet in the past 10 days to introduce you to the drug treatment plan for gastroesophageal refluxitis in detail and provide structured data for reference.
1. Common symptoms of gastroesophageal refluxitis
The main symptoms of gastroesophageal reflux disease include:
2. Commonly used drugs for gastroesophageal refluxitis
The following are commonly used drug categories and representative drugs for the treatment of gastroesophageal refluxitis:
| drug class | Mechanism of action | Representative medicine | Things to note |
|---|---|---|---|
| Proton pump inhibitors (PPIs) | Inhibit gastric acid secretion | Omeprazole, lansoprazole, pantoprazole | Be wary of the risk of osteoporosis with long-term use |
| H2 receptor antagonist | Reduce gastric acid secretion | ranitidine, famotidine | Less effective than PPI, but with fewer side effects |
| Antacids | Neutralize stomach acid | Aluminum hydroxide, calcium carbonate | Quickly relieves symptoms, but has a short duration of action |
| Gastrointestinal motility drugs | Accelerate gastric emptying | Domperidone, Mosapride | Need to be combined with other drugs for better effect |
| Mucosal protectant | Protect esophageal mucosa | Sucralfate, aluminum magnesium carbonate | Need to be taken on an empty stomach |
3. Selection of drug treatment options
Treatment options vary depending on the severity of the condition:
| Degree of illness | Recommended plan | Course of treatment |
|---|---|---|
| Mild GERD | Use antacids or H2 receptor antagonists as needed | Discontinue medication after symptoms subside |
| Moderate GERD | Standard dose PPI (once daily) | 4-8 weeks |
| Severe GERD | High-dose PPI (twice daily) or combination | 8-12 weeks or more |
| Refractory GERD | PPI + prokinetic drug + mucosal protective agent | individualized treatment |
4. Medication precautions
1. PPI drugs are recommended to be taken 30 minutes before breakfast for best results.
2. Avoid taking certain drugs together: for example, PPI may affect the efficacy of clopidogrel
3. Long-term use of PPI requires regular evaluation and supplementation of calcium and vitamin B12 when necessary.
4. When stopping the drug, the dose should be gradually reduced to avoid rebound gastric acid secretion.
5. Lifestyle adjustment
Medication needs to be combined with lifestyle changes for best results:
6. Latest research progress
According to recent popular medical information:
1. New potassium ion competitive acid blockers (P-CAB) such as vonoraxin have faster onset of action and longer-lasting acid suppression effect than traditional PPIs.
2. The technology of minimally invasive surgery to treat GERD is constantly improving, but patients who are ineffective in drug treatment still need to choose carefully.
3. Regulation of intestinal flora may become a new direction in the treatment of GERD, and relevant research is ongoing.
7. When Do You Need Medical Treatment?
You should seek medical treatment promptly if the following situations occur:
Summary: The drug treatment for gastroesophageal refluxitis needs to be selected according to individual conditions. Proton pump inhibitors are currently the most effective drugs, but care must be taken to use them rationally. With lifestyle adjustments and regular follow-up, most patients can achieve good control.
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